Morphometric Spatial Patterns Differentiating Boys With Fragile X Syndrome, Typically Developing Boys, and Developmentally Delayed Boys Aged 1 to 3 Years

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Morphometric spatial patterns differentiating boys with fragile X syndrome, typically developing boys, and developmentally delayed boys aged 1 to 3 years.

CONTEXT Brain maturation starts well before birth and occurs as a unified process with developmental interaction among different brain regions. Gene and environment play large roles in such a process. Studies of individuals with genetic disorders such as fragile X syndrome (FXS), which is a disorder caused by a single gene mutation resulting in abnormal dendritic and synaptic pruning, together ...

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Cortisol and Working Memory In Boys With Fragile X Syndrome

Shinkareva for their feedback and support throughout this process. iv ABSTRACT Fragile X Syndrome (FXS) is a neurodevelopmental disorder and the most common cause of inherited intellectual disability. Although FXS is associated with global cognitive impairments, specific deficits in working memory have been reported in young males with FXS. Working memory is an important cognitive process that ...

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Reading and phonological skills in boys with fragile X syndrome.

Although reading skills are critical for the success of individuals with intellectual disabilities, literacy has received little attention in fragile X syndrome (FXS). This study examined the literacy profile of FXS. Boys with FXS (n = 51; mean age 10.2 years) and mental age-matched boys with typical development (n = 35) participated in standardized assessments of reading and phonological skill...

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Finiteness marking in boys with fragile X syndrome.

PURPOSE The current study investigated finiteness marking (e.g., he walk s, he walk ed) in boys with fragile X syndrome (FXS); the boys were grouped based on receptive vocabulary (i.e., borderline, impaired). METHOD Twenty-one boys with the full mutation of fragile X, between the ages of 8 and 16 years participated. The boys completed probes from the Test of Early Grammatical Impairment (TE...

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Characterising repetitive behaviours in young boys with fragile X syndrome.

BACKGROUND Repetitive behaviours are frequently observed in individuals with intellectual disability (ID). The present study examined the profile, inter-correlations and predictive correlates of repetitive behaviours in boys with fragile X syndrome (FXS), the leading inherited cause of ID. Specific child characteristics examined as predictors included anxiety, nonverbal cognition and autism soc...

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ژورنال

عنوان ژورنال: Archives of General Psychiatry

سال: 2008

ISSN: 0003-990X

DOI: 10.1001/archpsyc.65.9.1087